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Inform patients about the risk for hypotension and syncope.
In 2003, the Movement Disorders Society Scientific Issues Committee Report (MDSSICR) reviewed these criteria.
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The study provides insight into how the stomach contracts before, during and after ingestion of meals and the varied gastrointestinal problems known to exist in AS.
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Standard drugs for Parkinson's disease, other than levodopa without a decarboxylase inhibitor, may be used concomitantly while SINEMET CR is being administered, although their dosage may have to be adjusted.
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These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions.
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Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever, and primary central nervous system (CNS) pathology.
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When decarboxylation of levodopa is prevented by carbidopa, COMT becomes the major metabolizing enzyme for levodopa, catalyzing its metabolism to 3-methoxy-4-hydroxy-L-phenylalanine (3-OMD).
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Although there may be resolution or improvement of impulse control disorders following STN DBS, the procedure may also induce, exacerbate, reveal, or have no effect on these conditions.
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Physicians should consider dose reduction or stopping Carbidopa Tablets or levodopa if a patient develops such urges while taking Carbidopa Tablets with carbidopa-levodopa.
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Additionally, the drug has significant side effects for some patients, including (involuntary movements and tics), hallucinations and illusions.
Valvular heart disease and the use of dopamine agonists for Parkinson's disease.
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When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic receptors, thereby compensating for the depleted supply of endogenous dopamine seen in Parkinson's disease.
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Gastrointestinal proceduralists received standardized instructions and training prior to performing the PEG-J procedure.
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Cochrane and PubMed databases from 1990 to 2008 found that these agents caused a 15% increase in adverse events such as somnolence, sudden-onset sleep, hallucinations, edema, and impulse control disorders (eg, pathologic gambling, shopping, and Internet use; hypersexuality; and hoarding).
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This is a decision you and your doctor will make.
Prior to the meeting, thought leaders in the field were asked to prepare presentations on the major disorders related to sleep disturbances in older adults, based upon their prevalence, potential morbidity and mortality, and possibility for response to therapy.
Before initiating treatment with SINEMET CR, advise patients about the potential to develop drowsiness and ask specifically about factors that may increase the risk for somnolence with SINEMET CR such as the use of concomitant sedating medications and the presence of sleep disorders.
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If genetic factors are important in a particular disease, concordance in genetically identical monozygotic (MZ) twins will be greater than in dizygotic (DZ) twins, who share only about 50% of genes.
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The expected incidence of fibrotic complications is so low that even if entacapone caused these complications at rates similar to those attributable to other dopaminergic therapies, it is unlikely that it would have been detected in a cohort of the size exposed to entacapone during its clinical development.
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