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Generic drugs manufacturers do not need to spend huge amounts on scientific research and development, on extensive clinical trials and marketing campaigns.
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ECOG trial comparing cisplatin-gemcitabine, cisplatin-paclitaxel, cisplatin-docetaxel, and carboplatin-paclitaxel, suggested similar overall response rates (approximately 19%), and median survival (7.
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This was approved in 2014 for people with metastatic ALK-positive lung cancer who cannot tolerate crizotinib or whose cancer continued to grow while being treated with crizotinib.
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The overall response rate was statistically greater for gefitinib than docetaxel (22.
Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer) Lancet.
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Fortunato Ciardiello, MD, professor of medical oncology at the Second University of Naples in Italy.
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The goal of systemic therapy for stage IV NSCLC is to keep the disease from growing and spreading.
An in-depth report on the causes, diagnosis, treatment, and prevention of non-small cell lung cancer (NSCLC).
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A generic drug is actually its brand-name equivalent, although it doesnt bear the original trademark and looks slightly different.
Monitor adverse reactions when administering strong CYP3A4 inhibitors with IRESSA.
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Our drug manufacturers perform a series of tests, both during and after production, to show that every drug meets the requirements for that product.
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This is accounted for by the possible differences in their inactive ingredients such as color and flavor additives, and by the copyright and trademark regulations that does not allow for exact copies of the existing brand-name products.
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The FDA-approved drug label for darifenacin (Enablex) notes that CYP2D6 poor metabolizers may have increased maximum plasma concentrations of darifenacin, as compared to CYP2D6 extensive metabolizers.
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First-line gefitinib in Caucasian EGFR mutation-positive NSCLC patients: a phase-IV, open-label, single-arm study.
The matter is that a manufacturer can not possess a patent for a certain chemical agent, this is why different manufacturers of generic drugs are able to produce the so-called generics legally.
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The characterization of circulating tumor cell might resolve the problem ultimately, since it is ascertain that the test was done on tumor cells.
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Despite its ubiquitous expression, inactivation of the EGFR gene in the mouse causes minimal defects, suggesting that pharmacologic inhibition of EGFR by gefitinib should have few adverse effects.
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